Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7)

Genomics. 1994 Jan 15;19(2):379-81. doi: 10.1006/geno.1994.1075.

Abstract

We have isolated cDNA and genomic clones coding for the human alpha 7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by alpha-bungarotoxin. The human alpha 7 neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat alpha 7 neuronal nicotinic subunit (90%). We have mapped the human alpha 7-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Aberrations / genetics
  • Chromosome Disorders
  • Chromosome Inversion
  • Chromosome Mapping
  • Chromosomes, Human, Pair 15*
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • Epilepsy / genetics
  • Genes*
  • Humans
  • Intellectual Disability / genetics
  • Mice
  • Molecular Sequence Data
  • Rats
  • Receptors, Nicotinic / genetics*
  • Sequence Homology, Nucleic Acid
  • Species Specificity
  • Syndrome
  • alpha7 Nicotinic Acetylcholine Receptor

Substances

  • Chrna7 protein, human
  • Chrna7 protein, mouse
  • Chrna7 protein, rat
  • DNA, Complementary
  • Receptors, Nicotinic
  • alpha7 Nicotinic Acetylcholine Receptor

Associated data

  • GENBANK/Z23141