Antipsoriatic effect of fumaric acid derivatives. Results of a multicenter double-blind study in 100 patients

J Am Acad Dermatol. 1994 Jun;30(6):977-81. doi: 10.1016/s0190-9622(94)70121-0.


Background: Psoriasis vulgaris may benefit from treatment with fumaric acid and/or its derivatives; however, because different preparations have been used, results have been contradictory and difficult to interpret.

Objective: The purpose of this clinical trial was to evaluate the therapeutic value of fumaric acid derivatives.

Methods: A randomized double-blind study was carried out in patients with psoriasis, comparing a well-characterized formulation of fumaric acid derivatives with placebo.

Results: The results indicated statistically significant superiority of the fumaric acid derivatives over placebo. Adverse events (flush, gastrointestinal disturbances) were initially relatively frequent, but decreased thereafter.

Conclusion: Fumaric acid derivatives were found to be effective and safe in the treatment of psoriasis.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Abdominal Pain / chemically induced
  • Adult
  • Aged
  • Diarrhea / chemically induced
  • Dimethyl Fumarate
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Flushing / chemically induced
  • Fumarates / administration & dosage
  • Fumarates / adverse effects
  • Fumarates / therapeutic use*
  • Humans
  • Joints / drug effects
  • Male
  • Middle Aged
  • Pain / physiopathology
  • Placebos
  • Psoriasis / drug therapy*
  • Psoriasis / physiopathology
  • Remission Induction


  • Drug Combinations
  • Fumarates
  • Placebos
  • Dimethyl Fumarate
  • ethyl fumarate