Transfer of elevated anti-S-100 autoimmunity from mother to offspring in rats

Life Sci. 1994;54(18):1377-81. doi: 10.1016/0024-3205(94)00517-6.

Abstract

Pregnant Wistar female rats were injected with polyclonal rabbit antibodies (AB) to S-100 brain protein. Control groups received equivalent amount of AB to bovine serum albumin or non-immune rabbit's IgG. An increased level of anti-S100 immunoreactivity was detected by ELISA or its enhanced variant ASPAG (from Amplified Solid Phase Attached Antigen-Antibody Grid formation) in the serum of 1 month old offsprings of group treated with AB to S-100. Obtained data indicate the possibility of inborn epigenetical "imprinting" of specific autoimmune reactions which may be important for the development of certain forms of nervous system diseases.

MeSH terms

  • Animals
  • Autoantibodies / blood*
  • Autoimmunity*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Immunity, Maternally-Acquired*
  • Pregnancy
  • Rabbits / immunology
  • Rats
  • Rats, Wistar
  • S100 Proteins / immunology*
  • Serum Albumin, Bovine / immunology

Substances

  • Autoantibodies
  • S100 Proteins
  • Serum Albumin, Bovine