Evidence for specific transport of uridine diphosphate galactose across the Golgi membrane of rat mammary gland

Biochem J. 1976 Jan 15;154(1):243-4. doi: 10.1042/bj1540243.

Abstract

The inhibition of lactose synthesis by UDP-glucose, UDP-glucuronate and, less so, by UDP-N-acetylglucosamine was markedly smaller in preparations of "intact" than of lysed vesicles derived from the Golgi apparatus of lactating rat mammary gland. This constitutes evidence for a specific, probably facilitated, transport of UDP-galactose across the Golgi membrane.

MeSH terms

  • Animals
  • Biological Transport
  • Female
  • Golgi Apparatus / metabolism*
  • Lactation
  • Lactose / metabolism
  • Lactose Synthase / antagonists & inhibitors
  • Mammary Glands, Animal / metabolism*
  • Mammary Glands, Animal / ultrastructure
  • Membranes / metabolism
  • Pregnancy
  • Rats
  • Uridine Diphosphate Galactose / metabolism*
  • Uridine Diphosphate Glucose / pharmacology
  • Uridine Diphosphate Glucuronic Acid / pharmacology
  • Uridine Diphosphate N-Acetylglucosamine / pharmacology
  • Uridine Diphosphate Sugars / metabolism*

Substances

  • Uridine Diphosphate Sugars
  • Uridine Diphosphate Glucuronic Acid
  • Uridine Diphosphate Galactose
  • Uridine Diphosphate N-Acetylglucosamine
  • Lactose Synthase
  • Lactose
  • Uridine Diphosphate Glucose