Progression of multifocal motor neuropathy during apparently successful treatment with human immunoglobulin

Neurology. 1994 May;44(5):967-8. doi: 10.1212/wnl.44.5.967.


We report a patient with multifocal motor neuropathy (MMN) who experienced a paradoxical decline in baseline strength to below pretreatment levels during a period of improvement associated with human immunoglobulin (HIG) administration. This outcome suggests that HIG may not limit progression of MMN and may reduce the utility of HIG as chronic therapy.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Immunoglobulins, Intravenous*
  • Male
  • Middle Aged
  • Motor Skills
  • Nervous System Diseases / therapy*


  • Immunoglobulins, Intravenous