The 3Rs of life: Ras, Raf and growth regulation

Trends Genet. 1994 Feb;10(2):44-8. doi: 10.1016/0168-9525(94)90147-3.

Abstract

Cellular Ras proteins are essential elements in normal signal transduction pathways while activated Ras proteins are prevalent in many different forms of human cancers. Here, we discuss the mechanism through which Ras proteins, either cellular or activated, transmit a proliferative signal by activating cytoplasmic serine/threonine kinases.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division / physiology*
  • Cytoplasm / enzymology
  • Genes, ras
  • Humans
  • Protein Serine-Threonine Kinases / metabolism
  • Protein Serine-Threonine Kinases / physiology*
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins c-raf
  • Proto-Oncogene Proteins p21(ras) / genetics
  • Proto-Oncogene Proteins p21(ras) / physiology*
  • Signal Transduction

Substances

  • Proto-Oncogene Proteins
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-raf
  • HRAS protein, human
  • Proto-Oncogene Proteins p21(ras)