Impaired growth in children with asthma during treatment with conventional doses of inhaled corticosteroids

Acta Paediatr. 1994 Feb;83(2):196-9. doi: 10.1111/j.1651-2227.1994.tb13050.x.


We describe 6 (4F, 2M) prepubertal children with moderate asthma diagnosed at a mean age of 2.8 years. All patients were treated with inhaled corticosteroids in a dose of between 300 and 800 mcg of beclomethasone dipropionate (becotide) daily, given either as an aerosol or rotahaler. Mean height velocity SDS decreased from -0.8 (range +0.5 to -2.0) to -3.2 (range -1.3 to -4.8) when the dose was increased. Alternatively, when the dose was reduced or stopped, mean height velocity SDS increased from -3.2 (range -2.0 to -4.8) to +0.8 (range -1.2 to +2.7). Careful assessment of height velocity is indicated in all children receiving treatment with inhaled corticosteroids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Asthma / drug therapy*
  • Beclomethasone / administration & dosage
  • Beclomethasone / adverse effects*
  • Body Height / drug effects
  • Child, Preschool
  • Female
  • Growth Disorders / chemically induced*
  • Humans
  • Infant
  • Male


  • Beclomethasone