Genetics of signal transduction in invertebrates

Curr Opin Genet Dev. 1994 Feb;4(1):64-70. doi: 10.1016/0959-437x(94)90092-2.


Receptor tyrosine kinases regulate a number of different cell fate decisions during invertebrate development. Genetic analysis of the signal transduction pathways activated by these kinases suggests that they converge upon a common pathway involving Ras and a cascade of cytoplasmic kinases, diverging again in the nucleus with the regulation of specific transcription factors.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Differentiation
  • Genes, ras
  • Invertebrates / genetics*
  • Invertebrates / physiology*
  • Molecular Sequence Data
  • Receptor Protein-Tyrosine Kinases / genetics
  • Receptor Protein-Tyrosine Kinases / physiology
  • Signal Transduction / genetics*


  • Receptor Protein-Tyrosine Kinases