Activators and effectors of ras p21 proteins

Curr Opin Genet Dev. 1994 Feb;4(1):71-6. doi: 10.1016/0959-437x(94)90093-0.

Abstract

Over the past year, major advances have been made in understanding the key steps involved in signaling pathways--from receptor tyrosine kinases to ras p21, and on to a cascade of serine/threonine kinases. A chain of specific protein-protein interactions is responsible for signal transduction. Components of the pathway are highly conserved between flies, nematodes and mammals, and constitute a primary signaling device in most cell types.

Publication types

  • Review

MeSH terms

  • Animals
  • GTPase-Activating Proteins
  • Genes, ras
  • Humans
  • Models, Biological
  • Oncogene Protein p21(ras) / genetics
  • Oncogene Protein p21(ras) / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism
  • Proteins / metabolism
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Signal Transduction
  • ras GTPase-Activating Proteins

Substances

  • GTPase-Activating Proteins
  • Proteins
  • ras GTPase-Activating Proteins
  • Receptor Protein-Tyrosine Kinases
  • Protein-Serine-Threonine Kinases
  • Oncogene Protein p21(ras)