Regulation and function of the Rho subfamily of small GTPases

Curr Opin Genet Dev. 1994 Feb;4(1):77-81. doi: 10.1016/0959-437x(94)90094-9.


During the past year, the small GTP-binding proteins Rho and Rac have each been shown to regulate a signal transduction pathway linking growth factor receptors to distinct changes in the actin cytoskeleton. A number of regulatory molecules for Rho-like proteins have been identified and some of these may cross-talk with the Ras signalling pathway.

Publication types

  • Review

MeSH terms

  • Animals
  • GTP-Binding Proteins / physiology*
  • GTPase-Activating Proteins*
  • Guanine Nucleotide Dissociation Inhibitors*
  • Humans
  • Models, Biological
  • Signal Transduction / physiology
  • rac GTP-Binding Proteins
  • rho-Specific Guanine Nucleotide Dissociation Inhibitors


  • GTPase-Activating Proteins
  • Guanine Nucleotide Dissociation Inhibitors
  • rho GTPase-activating protein
  • rho-Specific Guanine Nucleotide Dissociation Inhibitors
  • GTP-Binding Proteins
  • rac GTP-Binding Proteins