Ternary complex factors: growth factor regulated transcriptional activators

Curr Opin Genet Dev. 1994 Feb;4(1):96-101. doi: 10.1016/0959-437x(94)90097-3.


Members of a family of Ets domain proteins, the ternary complex factors (TCFs), are recruited to the c-fos serum response element by interaction with the serum response factor. Recent findings indicate that phosphorylation of TCFs occurs in response to activation of the MAP kinase pathway, and that regulation of TCF activity is an important mechanism by which the serum response element responds to growth factor signals.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • DNA-Binding Proteins / genetics
  • Fungal Proteins / genetics
  • Genes, fos
  • Growth Substances / physiology*
  • Humans
  • Molecular Sequence Data
  • Phosphorylation
  • Proto-Oncogene Proteins*
  • Retroviridae Proteins, Oncogenic / genetics
  • Trans-Activators / genetics
  • Trans-Activators / physiology*
  • Transcription Factors*
  • Transcription, Genetic
  • ets-Domain Protein Elk-1
  • ets-Domain Protein Elk-4


  • DNA-Binding Proteins
  • ELK4 protein, human
  • Fungal Proteins
  • Growth Substances
  • Proto-Oncogene Proteins
  • Retroviridae Proteins, Oncogenic
  • Trans-Activators
  • Transcription Factors
  • ets-Domain Protein Elk-1
  • ets-Domain Protein Elk-4