Effect of Artocarpus integer lectin on functional activity of guinea-pig complement

Immunol Invest. 1994 Mar;23(2):153-60. doi: 10.3109/08820139409087796.


The effect of Artocarpus integer lectin (lectin C) on the functional activity of guinea-pig complement was investigated. Purified and crude extract of lectin C from six cultivars of Artocarpus integer seeds were found to consume complement and thus decreased the complement-induced haemolytic activity of sensitized sheep erythrocytes. The change in the complement-mediated haemolytic activity was significantly decreased when incubation of the lectins was performed in the presence of melibiose. The reversal effect of the carbohydrate, which is a potent inhibitor of the lectin's binding to O-linked oligosaccharides of glycoprotein, demonstrate involvement of the lectins interaction with O-glycans of glycoproteins in the consumption of guinea-pig complement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Complement Hemolytic Activity Assay
  • Complement System Proteins / immunology*
  • Dose-Response Relationship, Drug
  • Erythrocytes / drug effects
  • Guinea Pigs
  • Interferon Inducers / pharmacology*
  • Lectins / pharmacology*
  • Plant Lectins*
  • Sheep


  • Interferon Inducers
  • Lectins
  • Plant Lectins
  • jacalin
  • Complement System Proteins