Physiologic support of the septic patient

Surg Clin North Am. 1994 Jun;74(3):637-58.


The patient's response to inflammation, referred to as sepsis, is a complex process involving the degree of the inflammatory insult and the host response. Ischemia, from blood flow abnormalities and direct cell injury from mediators, produces the physiologic response. The treatment is focused first on restoring and maintaining perfusion through maintenance of increased oxygen delivery. The second approach is first surgical then pharmacologic attenuation of the inflammation-induced injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Hemodynamics / physiology
  • Hormones / physiology
  • Humans
  • Inflammation / physiopathology
  • Multiple Organ Failure / physiopathology
  • Multiple Organ Failure / prevention & control*
  • Pain / physiopathology
  • Shock, Septic / physiopathology
  • Stress, Physiological / physiopathology
  • Surgical Wound Infection / drug therapy
  • Surgical Wound Infection / physiopathology
  • Surgical Wound Infection / therapy*


  • Hormones