A sib-pair approach to interval mapping of quantitative trait loci

Am J Hum Genet. 1994 Jun;54(6):1092-103.

Abstract

An interval mapping procedure based on the sib-pair method of Haseman and Elston is developed, and simulation studies are carried out to explore its properties. The procedure is analogous to other interval mapping procedures used with experimental material, such as plants and animals, and yields very similar results in terms of the location and effect size of a quantitative trait locus (QTL). The procedure offers an advantage over the conventional Haseman and Elston approach, in terms of power, and provides useful information concerning the location of a QTL. Because of its simplicity, the method readily lends itself to the analysis of selected samples for increased power and the evaluation of multilocus models of complex phenotypes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Chromosome Mapping / methods*
  • Chromosome Mapping / statistics & numerical data
  • Chromosomes, Human
  • Genetic Linkage*
  • Genetic Markers
  • Genotype
  • Humans
  • Models, Genetic*
  • Models, Statistical*

Substances

  • Genetic Markers