Neonatal adrenergic blockade following single dose maternal labetalol administration

Am J Perinatol. 1994 Mar;11(2):91-3. doi: 10.1055/s-2007-994563.


A single 30 mg intravenous dose of labetalol given 20 minutes prior to cesarean delivery at 35 weeks of gestation for severe pregnancy-induced hypertension was associated with symptoms of beta-adrenergic blockade (hypoglycemia, bradycardia, hypotension) in preterm twins. The infants were subsequently found to have therapeutic labetalol concentrations (180 and 150 ng/mL) in umbilical cord blood. The pharmacology of transplacental labetalol is reviewed and potential mechanisms for neonatal beta-adrenergic blockade are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bradycardia / chemically induced*
  • Diseases in Twins*
  • Female
  • Fetal Blood / chemistry
  • Humans
  • Hypoglycemia / chemically induced*
  • Hypotension / chemically induced*
  • Infant, Newborn
  • Labetalol / adverse effects*
  • Labetalol / blood
  • Male
  • Maternal-Fetal Exchange / physiology*
  • Pregnancy


  • Labetalol