The interleukin-8-receptor family: from chemokines to malaria

Immunol Today. 1994 Apr;15(4):169-74. doi: 10.1016/0167-5699(94)90314-X.


The interleukin 8 (IL-8)-receptor family includes two specific receptors (type A and B) that both bind IL-8 with high affinity. These receptors have been cloned, and belong to a superfamily of G-protein-linked receptors that signal in response to IL-8 on a variety of cell types. In contrast to these receptors, which have a narrow ligand-binding profile, a promiscuous IL-8 receptor has been found on human erythrocytes that binds a variety of chemokines with high affinity. This protein, known as the chemokine receptor, was recently shown to bind the malarial parasite Plasmodium vivax, and may play a major role in inflammation by limiting the concentration of soluble chemokines in the circulation.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Protozoan*
  • Chemotactic Factors / immunology
  • Cytokines / immunology
  • Erythrocytes / immunology
  • Humans
  • Interleukin-8 / immunology
  • Malaria / immunology
  • Molecular Sequence Data
  • Protozoan Proteins*
  • Receptors, Cell Surface / physiology
  • Receptors, Interleukin / chemistry*
  • Receptors, Interleukin / physiology*
  • Receptors, Interleukin-8A
  • Signal Transduction / immunology


  • Antigens, Protozoan
  • Chemotactic Factors
  • Cytokines
  • Duffy antigen binding protein, Plasmodium
  • Interleukin-8
  • Protozoan Proteins
  • Receptors, Cell Surface
  • Receptors, Interleukin
  • Receptors, Interleukin-8A