Controlled trial of zinc supplementation in anorexia nervosa

Int J Eat Disord. 1994 Apr;15(3):251-5.


Zinc supplementation of anorexia nervosa (AN) patients has been reported to increase the weight gain of AN patients in open trials. In this randomized, double-blind, placebo-controlled trial 100 mg of zinc gluconate, or placebo, was given daily to 35 female AN inpatients until they achieved a 10% increase in body mass index (BMI). The rate of increase in BMI of the zinc supplemented group (n = 16) was twice that of the placebo group (n = 19), and this difference was statistically significant (p = .03). The use of zinc supplementation should be considered in the treatment of AN patients.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anorexia Nervosa / drug therapy*
  • Body Mass Index
  • Combined Modality Therapy
  • Double-Blind Method
  • Enteral Nutrition
  • Female
  • Gluconates / administration & dosage*
  • Humans
  • Weight Gain / drug effects*


  • Gluconates
  • gluconic acid