Acyclovir-resistant Neonatal Herpes Simplex Virus Infection of the Larynx

J Pediatr. 1994 Jun;124(6):967-71. doi: 10.1016/s0022-3476(05)83194-4.

Abstract

A 10-day-old infant with stridor was found to have herpes simplex virus type 2 infection of the larynx. The infant's poor clinical response to both acyclovir and foscarnet prompted extensive clinical and virologic evaluations, which revealed acyclovir-resistant herpes simplex virus.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / pharmacology
  • Acyclovir / therapeutic use*
  • Drug Resistance, Microbial
  • Female
  • Foscarnet / therapeutic use
  • Herpes Simplex / drug therapy*
  • Herpesvirus 2, Human / drug effects*
  • Herpesvirus 2, Human / isolation & purification
  • Humans
  • Infant, Newborn
  • Laryngeal Diseases / drug therapy*
  • Laryngeal Diseases / microbiology

Substances

  • Foscarnet
  • Acyclovir