Antineutrophil cytoplasmic autoantibody-positive crescentic glomerulonephritis as a complication of treatment with propylthiouracil in children

J Pediatr. 1994 Jun;124(6):986-8. doi: 10.1016/s0022-3476(05)83199-3.


Propylthiouracil, which is commonly used in the treatment of hyperthyroidism, has been associated in adults with antineutrophil cytoplasmic autoantibody, a serologic marker of vasculitis. Severe renal disease has not been reported as a complication of therapy with this drug. We report severe antineutrophil cytoplasmic autoantibody-positive vasculitis in children receiving propylthiouracil, as well as rapidly progressive crescentic glomerulonephritis after administration of this drug.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies / analysis*
  • Biomarkers / analysis
  • Child
  • Female
  • Glomerulonephritis / chemically induced*
  • Glomerulonephritis / immunology
  • Humans
  • Hyperthyroidism / drug therapy
  • Male
  • Propylthiouracil / adverse effects*
  • Propylthiouracil / therapeutic use


  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies
  • Biomarkers
  • Propylthiouracil