Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate

Antimicrob Agents Chemother. 1976 Jun;9(6):951-5. doi: 10.1128/AAC.9.6.951.

Abstract

A new 3-N-aminoglycoside acetyltransferase is described, which possesses a wider substrate range than any such enzyme so far discovered in clinical isolates of antibiotic-resistant bacteria.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetyltransferases / analysis*
  • Aminoglycosides / metabolism*
  • Anti-Bacterial Agents / metabolism*
  • Biodegradation, Environmental
  • Escherichia coli / metabolism
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / enzymology*
  • Sisomicin / metabolism

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Acetyltransferases
  • Sisomicin