Fatty acids and other compounds with nematicidal activity from cultures of Basidiomycetes

Planta Med. 1994 Apr;60(2):128-32. doi: 10.1055/s-2006-959433.


In a screening for nematicidal activities in cultures of Basidiomycetes, cultures of Pleurotus pulmonarius and Hericium coralloides exhibited toxic effects towards the saprophytic nematode Caenorhabditis elegans. Subsequently S-coriolic acid (1), linoleic acid (2), p-anisaldehyde (3), p-anisyl alcohol (4), 1-(4-methoxyphenyl)-1,2-propanediol (5), and 2-hydroxy-(4'-methoxy)-propiophenone (6) were isolated from submerged cultures of P. pulmonarius. All compounds showed nematicidal activities towards C. elegans. The most active compounds were 1 and 2 with LD50 values between 5 and 10 ppm. Compounds 1, 4, and 5 have not been previously isolated from higher fungi, 6 is a new natural product. From cultures of H. coralloides, which exhibited both repellant and nematicidal effects, a nematicidal fatty acid mixture was obtained, containing linoleic acid, oleic acid, and palmitic acid as its main components.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antinematodal Agents / chemistry
  • Antinematodal Agents / isolation & purification
  • Antinematodal Agents / pharmacology*
  • Basidiomycota / chemistry*
  • Caenorhabditis elegans / drug effects
  • Fatty Acids / chemistry
  • Fatty Acids / isolation & purification
  • Fatty Acids / pharmacology*
  • Polyporaceae / chemistry


  • Antinematodal Agents
  • Fatty Acids