Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis

Planta Med. 1994 Apr;60(2):133-5. doi: 10.1055/s-2006-959434.


Asiatic acid, madecassic acid, and asiaticoside, terpenoids with an ursane skeleton, were tested separately and in combination on skin human fibroblast collagen I synthesis in vitro. In the absence of ascorbic acid, the mixture as well as each individual component stimulated collagen I synthesis to a similar extent. In the presence of ascorbic acid, the level of collagen I secretion was higher for each individual component and for the mixture. A comparison of asiaticoside and asiatic acid shows that the sugar moiety of the molecule does not seem to be necessary for this biological activity.

MeSH terms

  • Adult
  • Carbohydrate Sequence
  • Cells, Cultured
  • Collagen / biosynthesis*
  • Humans
  • Molecular Sequence Data
  • Pentacyclic Triterpenes
  • Terpenes / pharmacology*
  • Triterpenes / pharmacology*


  • Pentacyclic Triterpenes
  • Terpenes
  • Triterpenes
  • Collagen
  • asiatic acid
  • madecassic acid
  • asiaticoside