Fisher's game with the devil

Stat Med. 1994 Feb 15;13(3):217-30. doi: 10.1002/sim.4780130305.


The publication of Fisher's correspondence on statistics has shed new light on his views on randomization. Quotations from this correspondence and from other works of Fisher are used to illustrate the role of randomization in clinical trials. It is concluded that Fisher's views not only are coherent but, despite having been developed over 60 years ago and with particular reference to agricultural experiments, are still relevant to the planning and analysis of clinical trials today.

MeSH terms

  • Bayes Theorem
  • Bias
  • Data Interpretation, Statistical*
  • Double-Blind Method
  • Humans
  • Random Allocation*
  • Randomized Controlled Trials as Topic*
  • Single-Blind Method