DRTF1/E2F: An Expanding Family of Heterodimeric Transcription Factors Implicated in Cell-Cycle Control

Trends Biochem Sci. 1994 Mar;19(3):108-14. doi: 10.1016/0968-0004(94)90202-x.

Abstract

During the cell cycle, the transcription of certain genes is integrated with cell-cycle progression, thus providing an important level of control. In mammalian cells, DRTF1/E2F is a transcription activity comprising a group of related heterodimeric transcription factors that function in this integration process. The primary molecules involved in generating the afferent signals that converge on DRTF1/E2F belong to a class of proteins, exemplified by the retinoblastoma tumour suppressor gene product, whose activities are, in turn, regulated by cyclin-dependent kinases. The transcriptional activity of DRTF1/E2F is therefore regulated through a pathway that links the machinery of the cell cycle to the transcription apparatus. As such, it is likely to play a pivotal role in regulating cell-cycle progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Carrier Proteins*
  • Cell Cycle / genetics*
  • Cell Cycle Proteins*
  • DNA-Binding Proteins*
  • E2F Transcription Factors
  • Molecular Sequence Data
  • Retinoblastoma-Binding Protein 1
  • Transcription Factors / genetics*

Substances

  • Carrier Proteins
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • Retinoblastoma-Binding Protein 1
  • Transcription Factors