Cough variant asthma: a case study with antigen, histamine and methacholine inhalation challenge tests

Acta Paediatr Jpn. 1994 Apr;36(2):223-6. doi: 10.1111/j.1442-200x.1994.tb03167.x.


This paper presents a 7 year old girl with cough variant asthma, in which house dust challenge test provoked fine crackles on auscultation without any changes of lung function test. Pretreatment with DL-chlorpheniramine maleate for 7 days inhibited the appearance of fine crackles. On histamine inhalation test, fine crackles and rhonchi appeared on auscultation without bronchoconstriction (% fall of one-second forced expiratory volume < 10%). These data suggest that the cause of cough variant asthma is mainly an immunoglobulin E-mediated allergic reaction in the mucus secreting system.

Publication types

  • Case Reports

MeSH terms

  • Asthma / physiopathology*
  • Bronchial Provocation Tests
  • Child
  • Cough / physiopathology*
  • Dust*
  • Female
  • Histamine*
  • Humans
  • Methacholine Chloride*


  • Dust
  • Methacholine Chloride
  • Histamine