Chromatographic studies of the enantiomeric composition of some therapeutic compositions applied in the treatment of liver and kidney diseases

J Chromatogr A. 1994 Apr 8;665(1):67-73. doi: 10.1016/0021-9673(94)87033-0.


A gas-liquid chromatographic system with alpha-cyclodextrin in formamide medium (coated on Chromosorb) was used for the separation of enantiomers of alpha-pinene, beta-pinene, limonene and camphene in medicines applied in the therapy of liver and kidney diseases. The drugs under investigation were produced in Poland (Terpichol and Terpinex), in Germany (Rowachol and Rowatinex) and in Slovenia (Uroterp). It was found that, depending on the manufacturer, medicines possessing similar chemical compositions differ considerably from one another regarding the content of enantiomers, mainly those of alpha-pinene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bicyclic Monoterpenes
  • Bridged Bicyclo Compounds / chemistry*
  • Bridged Bicyclo Compounds / isolation & purification
  • Bridged Bicyclo Compounds / therapeutic use
  • Chromatography, Gas
  • Cyclohexenes
  • Drug Combinations
  • Flame Ionization
  • Humans
  • Kidney Diseases / drug therapy*
  • Limonene
  • Liver Diseases / drug therapy*
  • Monoterpenes*
  • Stereoisomerism
  • Terpenes / chemistry*
  • Terpenes / isolation & purification
  • Terpenes / therapeutic use


  • Bicyclic Monoterpenes
  • Bridged Bicyclo Compounds
  • Cyclohexenes
  • Drug Combinations
  • Monoterpenes
  • Terpenes
  • beta-pinene
  • Rowachol
  • Rowatinex
  • Limonene
  • camphene
  • alpha-pinene