Acute inflammatory polyarthritis in association with tamoxifen

Br J Rheumatol. 1994 Jun;33(6):583-5. doi: 10.1093/rheumatology/33.6.583.


The antioestrogen drug tamoxifen is widely used to treat breast carcinoma. We report three cases in which its use was temporally related to the development of an acute inflammatory polyarthritis resembling RA; a side-effect not previously reported. Possible mechanisms for such an effect are discussed.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Arthritis / chemically induced*
  • Breast Neoplasms / drug therapy*
  • Carcinoma / drug therapy*
  • Female
  • Humans
  • Middle Aged
  • Tamoxifen / administration & dosage
  • Tamoxifen / adverse effects*


  • Tamoxifen