Human papillomavirus infections of the genital region in human immunodeficiency virus seropositive women: integration of type 16 correlates with rapid progression

Eur J Gynaecol Oncol. 1994;15(1):50-8.


The efficacy of treatment of HPV infections was evaluated in 14 HIV-1 seropositive women. Disease evolution was evaluated at follow-up examinations, and findings were compared to those in 14 historic HIV-negative women who had received similar treatment. HPV sequences were demonstrated by Southern blot in 13/14 HIV-positive women and by in situ hybridization in 5/13 HIV-negative women. Types 6/11, 16, and 31/33/35 were equally distributed in both groups; type 18 was never detected. In all but one case, the same viral type was present in different lesions, and in recurrences. Among the HIV-positive women, integration of viral sequences had occurred in the dysplastic lesions in 2 of the 3 HPV-16-positive cases; both cases showed progression to carcinoma in situ within 1 to 2 years. Despite comparable treatment, the HIV-positive women showed lesion persistence or progression, while all HIV-negative women experienced regression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Carcinoma in Situ / virology
  • Cell Transformation, Neoplastic
  • Condylomata Acuminata / virology
  • DNA, Viral / analysis
  • Female
  • Follow-Up Studies
  • Genital Diseases, Female / complications
  • Genital Diseases, Female / virology*
  • Genital Neoplasms, Female / virology
  • HIV Seropositivity / complications*
  • HIV-1*
  • Humans
  • Middle Aged
  • Papillomaviridae* / genetics
  • Papillomaviridae* / isolation & purification
  • Papillomavirus Infections / complications*
  • Retrospective Studies
  • Tumor Virus Infections / complications*


  • DNA, Viral