Antinociceptive effect of L-arginine in diabetic mice

Eur J Pharmacol. 1994 Mar 11;254(1-2):113-7. doi: 10.1016/0014-2999(94)90377-8.

Abstract

The antinociceptive effect of L-arginine in streptozotocin-induced diabetic mice was examined. Although s.c. administration of L-arginine produced a dose-dependent inhibition of the tail-flick response in both non-diabetic and diabetic mice, the antinociceptive response was greater in diabetic mice than in non-diabetic mice. The antinociceptive effects of L-arginine in both diabetic and non-diabetic mice were significantly antagonized by s.c. administration of naltrindole, a selective delta-opioid receptor antagonist. However, neither beta-funaltrexamine, a selective mu-opioid receptor antagonist, nor nor-binaltorphimin ++, a selective kappa-opioid receptor antagonist, significantly affected the antinociceptive effect of L-arginine in diabetic and non-diabetic mice. These results suggest that L-arginine produces a marked antinociceptive effect in diabetic mice through the activation of delta-opioid receptors.

MeSH terms

  • Analgesics / administration & dosage
  • Analgesics / antagonists & inhibitors
  • Analgesics / pharmacology*
  • Animals
  • Arginine / administration & dosage
  • Arginine / analogs & derivatives
  • Arginine / antagonists & inhibitors
  • Arginine / pharmacology*
  • Diabetes Mellitus, Experimental / physiopathology*
  • Dose-Response Relationship, Drug
  • Endorphins / administration & dosage
  • Endorphins / pharmacology
  • Injections, Intraventricular
  • Injections, Subcutaneous
  • Male
  • Mice
  • Mice, Inbred ICR
  • Naltrexone / analogs & derivatives
  • Naltrexone / pharmacology
  • Narcotic Antagonists / pharmacology
  • Nitroarginine
  • Pain Measurement / drug effects
  • Reaction Time / drug effects

Substances

  • Analgesics
  • Endorphins
  • Narcotic Antagonists
  • kyotorphin
  • Nitroarginine
  • norbinaltorphimine
  • Naltrexone
  • beta-funaltrexamine
  • Arginine
  • naltrindole