A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII

Gene. 1994 Jun 10;143(2):285-7. doi: 10.1016/0378-1119(94)90112-0.


A 1.2-kb cDNA clone isolated from a HeLa cell library contains an open reading frame encoding a new protein (p21) of 21 kDa that is approx. 48% similar to members of the eukaryotic transcription elongation factor SII (TFIIS) family. The deduced amino-acid sequence of p21 indicates that it is hydrophilic, basic and contains nuclear localization signals, as well as multiple consensus phosphorylation sites.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • DNA, Complementary / genetics
  • DNA-Binding Proteins / chemistry*
  • DNA-Binding Proteins / genetics
  • HeLa Cells
  • Humans
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Transcription Factors / chemistry*
  • Transcription Factors / genetics
  • Transcription Factors, General*
  • Transcriptional Elongation Factors*


  • DNA, Complementary
  • DNA-Binding Proteins
  • TCEAL1 protein, human
  • Transcription Factors
  • Transcription Factors, General
  • Transcriptional Elongation Factors
  • transcription factor S-II

Associated data

  • GENBANK/M99701
  • GENBANK/X57198