Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA

Gene. 1994 Jun 10;143(2):295-8. doi: 10.1016/0378-1119(94)90114-7.


We have isolated cDNAs for the human TRP-2 gene which represents a third member of the tyrosinase-related gene family and encodes the dopachrome tautomerase activity that functions in the synthesis of melanin pigment. The human TRP-2 protein has 83% identity/90% similarity to the mouse sequence and has all the structural characteristics of the tyrosinase protein family, including a signal peptide, 15 conserved cysteine residues, two copper-binding domains and a C-terminal membrane-spanning region. Northern blot analysis reveals that TRP-2 is expressed at high levels in human melanoma cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Complementary / chemistry
  • DNA, Complementary / genetics
  • Humans
  • Intramolecular Oxidoreductases*
  • Isomerases / chemistry
  • Isomerases / genetics*
  • Melanoma / enzymology
  • Mice
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Tumor Cells, Cultured


  • DNA, Complementary
  • Isomerases
  • Intramolecular Oxidoreductases
  • dopachrome isomerase

Associated data

  • GENBANK/L18967