The subunit composition of a GABAA/benzodiazepine receptor from rat cerebellum

J Neurochem. 1994 Jul;63(1):371-4. doi: 10.1046/j.1471-4159.1994.63010371.x.

Abstract

The pentameric subunit composition of a large population (36%) of the cerebellar granule cell GABAA receptors that show diazepam (or clonazepam)-insensitive [3H]Ro 15-4513 binding has been determined by immunoprecipitation with subunit-specific antibodies. These receptors have alpha 6, alpha 1, gamma 2S, gamma 2L, and beta 2 or beta 3 subunits colocalizing in the same receptor complex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies / analysis
  • Antibodies / immunology
  • Cerebellum / chemistry*
  • Cerebellum / cytology
  • Cerebellum / ultrastructure
  • Diazepam / pharmacology
  • Molecular Sequence Data
  • Precipitin Tests
  • Rats
  • Receptors, GABA-A / analysis*
  • Receptors, GABA-A / chemistry
  • Receptors, GABA-A / immunology

Substances

  • Antibodies
  • Receptors, GABA-A
  • Diazepam