Cetyl myristoleate isolated from Swiss albino mice: an apparent protective agent against adjuvant arthritis in rats

J Pharm Sci. 1994 Mar;83(3):296-9. doi: 10.1002/jps.2600830307.

Abstract

Cetyl myristoleate was isolated from National Institutes of Health, general purpose, Swiss albino mice that were immune to the polyarthritis induced in rats with Freund's adjuvant. This substance, or material synthesized from cetyl alcohol and myristoleic acid, afforded good protection against adjuvant-induced arthritic states in rats. In limited comparisons, cetyl oleate, also found in Swiss albino mice, gave lesser protection, whereas cetyl myristate and cetyl elaidate, the trans-isomer of cetyl oleate, appeared to be virtually ineffective. Dosage of the protective compound as well as the site of injection of Freund's adjuvant was important.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Arthritis, Experimental / pathology
  • Arthritis, Experimental / prevention & control*
  • Freund's Adjuvant
  • Hindlimb / pathology
  • Hydrolysis
  • Male
  • Mice
  • Mycobacterium / immunology
  • Rats
  • Rats, Sprague-Dawley
  • Waxes / chemical synthesis
  • Waxes / isolation & purification
  • Waxes / therapeutic use*
  • Weight Gain / drug effects

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Waxes
  • cetyl myristoleate
  • Freund's Adjuvant