[Interaction of heparinized polymer materials with plasma proteins and thrombocytes]

Med Tekh. 1994 Mar-Apr:(2):18-22.
[Article in Russian]

Abstract

The interaction of heparinized polymer materials with human plasma proteins (serum albumin (SA), fibrinogen (F), antithrombin III (AT-III)) and platelets was studied. The level of SA and F adsorption irreversibility was demonstrated to depend on the mode of heparin immobilization. There was a negative correlation between the parameters of protein adsorption and the level of adsorbed AT-III. The relationship of the count of platelets adhered to the surface of heparinized polymer materials, to the time of contact was shown to be extreme. There was a correlation between the count of adhesive platelets and the parameters of plasma protein and AT-III adsorption. Based on experimental evidence, a scheme was proposed, which describes the impact of protein adsorption processes on the anticoagulative activity of surface-bound heparin, It is concluded that AT-III plays a particular role as the major component of the adsorption layer that is responsible for the nature of interactions of polymer materials with blood at the protein and cellular levels.

Publication types

  • English Abstract

MeSH terms

  • Adsorption
  • Antithrombin III / metabolism*
  • Blood Coagulation / drug effects
  • Blood Platelets / metabolism*
  • Fibrinogen / metabolism*
  • Heparin / pharmacokinetics*
  • Humans
  • Platelet Adhesiveness / drug effects
  • Polymers / pharmacokinetics*
  • Serum Albumin / metabolism*

Substances

  • Polymers
  • Serum Albumin
  • Antithrombin III
  • Fibrinogen
  • Heparin