Early diagnosis of breast cancer dissemination by tumor markers follow-up and method of prediction

M Nekulová; M Simícková; L Pecen; K Eben; I Vermousek; P Stratil; M Cernoch; B Lang

Early diagnosis of breast cancer dissemination by tumor markers follow-up and method of prediction

Neoplasma. 1994;41(2):113-8.

Authors

M Nekulová¹, M Simícková, L Pecen, K Eben, I Vermousek, P Stratil, M Cernoch, B Lang

Affiliation

¹ Masaryk Memorial Cancer Institute, Brno, Czech Republic.

PMID: 8208314

Abstract

A mathematical model of prediction of progression was tested in patients with breast cancer employing long-term monitoring of tumor markers CEA, CA 15-3, MCA and TPA, erythrocyte sedimentation rate (FW), and the enzymes gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP) and lactate dehydrogenase (LD) in serum. At the same time, specificity, sensitivity, lead time and positive predictive value were evaluated along with false positivity for all these parameters and their combinations. A model was proposed for the follow-up of patients with breast cancer after the completion of basic therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigens, Tumor-Associated, Carbohydrate / analysis
Biomarkers, Tumor / analysis*
Breast Neoplasms / diagnosis*
Carcinoembryonic Antigen / analysis
Female
Follow-Up Studies
Humans
Mathematics
Middle Aged
Neoplasm Metastasis / diagnosis
ROC Curve

Substances

Antigens, Tumor-Associated, Carbohydrate
Biomarkers, Tumor
Carcinoembryonic Antigen