Neurological complications in children with protein C deficiency

Neuropediatrics. 1994 Feb;25(1):16-9. doi: 10.1055/s-2008-1071575.


Four children with a cerebrovascular occlusive accident and protein C deficiency are described. Two patients presented with an acute hemiplegia, the others suffered from a transient ischemic attack and a progressive hydrocephalus as the result of sinus thrombosis. In all cases protein C deficiency, Type 1, was diagnosed. Other causes of cerebrovascular disease were excluded. Although venous thrombosis has been extensively reported in protein C deficiency, these cases indicate that protein C deficiency is also related to arterial thrombosis. In evaluating children with cerebrovascular accidents, protein C deficiency should also be considered.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain / diagnostic imaging
  • Brain / physiopathology
  • Cerebrovascular Disorders / diagnosis
  • Cerebrovascular Disorders / etiology*
  • Cerebrovascular Disorders / physiopathology
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Infant
  • Male
  • Protein C Deficiency*
  • Protein Deficiency / complications*
  • Protein Deficiency / diagnosis
  • Protein Deficiency / genetics
  • Tomography, X-Ray Computed