Cigarette smoke aggravates acid-induced duodenal mucosal injury in the rat. Role of mesenteric vasoconstriction

Scand J Gastroenterol. 1994 Mar;29(3):214-8. doi: 10.3109/00365529409090466.


In anesthetized rats we tested the hypothesis that cigarette smoke potentiates acid-induced duodenal mucosal injury by inducing mesenteric vasoconstriction. Rats inhaled room air or 6 or 12 ml/min cigarette smoke. Study 1: 0.1 N HCl-induced duodenal mucosal injury and H+ loss were assessed by histologic evaluation and titration, respectively. Study 2: Superior mesenteric artery blood flow was assessed by pulsed Doppler flowmetry before and during inhalation of cigarette smoke or room air. Twelve milliliter per minute of cigarette smoke aggravated 0.1 N HCl-induced duodenal mucosal injury by significantly increasing the number of villi with deep villous damage. The increased damage was associated with significantly greater loss of H+ from the duodenal lumen. Cigarette smoke produced a dose-related reduction in mesenteric blood flow. We conclude that the vasoconstrictive effect of cigarette smoke on mesenteric blood flow may be involved in the potentiation of acid-induced duodenal mucosal injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Duodenal Ulcer / chemically induced
  • Duodenal Ulcer / etiology*
  • Duodenal Ulcer / physiopathology
  • Hydrochloric Acid
  • Intestinal Mucosa / pathology
  • Male
  • Mesenteric Artery, Superior / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • Regional Blood Flow
  • Smoking / adverse effects*
  • Vasoconstriction / physiology*


  • Hydrochloric Acid