Mitral valve disease associated with long-term ergotamine use

South Med J. 1993 Oct;86(10):1179-81. doi: 10.1097/00007611-199310000-00024.


A 43-year-old woman with symptoms and signs of congestive heart failure and intermittent claudication was found to have moderately severe mitral stenosis and regurgitation, as well as severe bilateral upper and lower extremity arterial occlusive disease. She had a history of migraine headaches and had abused ergotamine tartrate (Cafergot) chronically for more than 20 years. Only rare instances of valvular heart disease have been associated with chronic ergotamine toxicity, with the majority of previously reported cases based on auscultatory findings alone.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Arterial Occlusive Diseases / etiology*
  • Brachial Artery*
  • Cardiac Catheterization
  • Chronic Disease
  • Coronary Angiography
  • Echocardiography
  • Ergotamine*
  • Female
  • Femoral Artery*
  • Gated Blood-Pool Imaging
  • Heart Auscultation
  • Heart Failure / etiology*
  • Humans
  • Intermittent Claudication / etiology*
  • Migraine Disorders / drug therapy*
  • Mitral Valve Insufficiency / chemically induced*
  • Mitral Valve Insufficiency / complications
  • Mitral Valve Insufficiency / diagnosis
  • Mitral Valve Insufficiency / drug therapy
  • Mitral Valve Stenosis / chemically induced*
  • Mitral Valve Stenosis / complications
  • Mitral Valve Stenosis / diagnosis
  • Mitral Valve Stenosis / drug therapy
  • Substance-Related Disorders / complications*


  • Ergotamine