Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Sep 10;193(4257):1017-20.
doi: 10.1126/science.821146.

Complete Covalent Structure of a Human IgA1 Immunoglobulin

Complete Covalent Structure of a Human IgA1 Immunoglobulin

Y S Liu et al. Science. .

Abstract

The complete covalent structure has been determined for a human myeloma IgA1 immunoglobulin. This protein has unique features in the amino acid sequence and disulfide bridge structure of the variable (V) and constant (C) regions of both the alpha heavy and the lambda light chains, and in the number and loci of oligosaccharides. Whereas C region domains of heavy chains have evolved independently over eons, recent isotypic variations have occured in lambda light chains and possibly in alpha heavy chains.

Similar articles

See all similar articles

Cited by 29 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback