Cerebral aspergillosis in immunologically competent patients

Surg Neurol. 1993 Oct;40(4):326-31. doi: 10.1016/0090-3019(93)90145-q.


Aspergillosis of the central nervous system is a rare disease, especially if the patient's immune system is not compromised. The authors report three cases of cerebral aspergillosis in the immunocompetent state: a rhinocerebral form in a diabetic patient, a direct extension from chronic Aspergillus otitis media, and a postoperative Aspergillus brain abscess after brain tumor surgery. In spite of the poor prognosis of cerebral aspergillosis, two of the patients survived. The pathogenesis, predisposing factors, radiologic findings including magnetic resonance image, and the outcome are presented. The pertinent literature of cerebral aspergillosis is also reviewed.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aspergillosis / complications
  • Aspergillosis / drug therapy
  • Aspergillosis / immunology*
  • Brain Abscess / diagnostic imaging
  • Brain Abscess / microbiology
  • Brain Diseases / complications
  • Brain Diseases / drug therapy
  • Brain Diseases / immunology*
  • Diabetes Complications
  • Female
  • Humans
  • Immunocompetence*
  • Magnetic Resonance Imaging
  • Male
  • Meningeal Neoplasms / surgery
  • Meningioma / surgery
  • Middle Aged
  • Nose Diseases / immunology
  • Nose Diseases / microbiology
  • Otitis Media / microbiology
  • Postoperative Complications
  • Tomography, X-Ray Computed