The Effector Interactions of p21ras

Trends Biochem Sci. 1993 Jul;18(7):250-4. doi: 10.1016/0968-0004(93)90175-m.

Abstract

Genetic, physical and biochemical methods have been used successfully to identify discrete regions of the p21ras protein involved in protein-protein interactions. Of special interest are the effector residues of p21ras, which are essential for downstream signalling. This review details current understanding of what these residues are and how they bind and activate proteins essential to the ras pathway.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • GTPase-Activating Proteins
  • Genes, ras
  • Molecular Sequence Data
  • Mutagenesis, Site-Directed
  • Protein Binding
  • Protein Structure, Tertiary
  • Proteins / genetics
  • Proteins / metabolism*
  • Proto-Oncogene Proteins p21(ras) / genetics
  • Proto-Oncogene Proteins p21(ras) / metabolism*
  • Signal Transduction
  • ras GTPase-Activating Proteins

Substances

  • GTPase-Activating Proteins
  • Proteins
  • ras GTPase-Activating Proteins
  • Proto-Oncogene Proteins p21(ras)