In situ preservation of kidneys from non-heart-beating donors--a proposal for a standardized protocol

Transplantation. 1993 Sep;56(3):613-7. doi: 10.1097/00007890-199309000-00022.

Abstract

The growing success in renal transplantation has resulted in an increase in the need for donor organs. Procurement of kidneys from heart-beating (HB) donors is unlikely ever to meet this demand. Non-heart-beating (NHB) donors offer a yet untapped source of renal grafts. Cadaver kidneys from patients who have sustained cardiac standstill are often considered unsuitable for transplantation due to prolonged warm ischemia time. Using an emergency in situ perfusion technique it is possible to limit warm ischemic damage and to salvage these kidneys for transplantation. The procedure requires prompt action and cooperation of emergency service personnel. This report presents a protocol for the emergency in situ preservation procedure that can be practiced in most hospitals. At the University Hospital of Maastricht, The Netherlands, implementation of this procedure resulted in 20% more kidneys available for transplantation. Although NHB donor kidneys showed a higher rate of delayed function compared with a matched HB donor kidney population, there was no significant difference in long-term graft survival between the two groups.

MeSH terms

  • Brain Death
  • Cadaver
  • Graft Survival
  • Heart Arrest*
  • Humans
  • Kidney*
  • Organ Preservation / standards*
  • Tissue Donors*
  • Tissue and Organ Procurement / legislation & jurisprudence
  • Tissue and Organ Procurement / organization & administration
  • Tissue and Organ Procurement / standards*