Effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis in rats

Agents Actions. 1993 Mar;38(3-4):240-6. doi: 10.1007/BF01976216.

Abstract

The prophylactic and therapeutic effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis (CIA) were evaluated in DA rats. Prophylactic treatment with cyclosporin A and cyclophosphamide suppressed the arthritis incidence, clinical inflammation, destructive bone changes, and development of anti-collagen antibody in DA rats subsequently injected with porcine type-II collagen. Therapeutic treatment with cyclosporin A and cyclophosphamide had a definite suppression on established CIA when started 21 days after the initial collagen injection, but the suppression was less marked than that of prophylactic treatment. Gold had no impact on CIA in DA rats when administered either prophylactically or therapeutically.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Arthritis, Experimental / chemically induced
  • Arthritis, Experimental / drug therapy*
  • Arthritis, Experimental / prevention & control
  • Autoantibodies / analysis
  • Collagen / administration & dosage
  • Collagen / immunology
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / therapeutic use*
  • Cyclosporine / administration & dosage
  • Cyclosporine / therapeutic use*
  • Disease Models, Animal
  • Enzyme-Linked Immunosorbent Assay
  • Gold Sodium Thiomalate / administration & dosage
  • Gold Sodium Thiomalate / therapeutic use*
  • Injections, Subcutaneous
  • Random Allocation
  • Rats

Substances

  • Autoantibodies
  • Gold Sodium Thiomalate
  • Cyclosporine
  • Cyclophosphamide
  • Collagen