Selective brain cooling increases cortical cerebral blood flow in rats

Am J Physiol. 1993 Sep;265(3 Pt 2):H824-7. doi: 10.1152/ajpheart.1993.265.3.H824.


To evaluate the effect of selective brain cooling on cortical cerebral blood flow, we reduced brain temperature in nitrous oxide anesthetized adult rats using a high speed fan while keeping rectal temperature at 37-38 degrees C. During selective brain cooling, cortical cerebral blood flow, as measured by laser-Doppler flowmetry, increased to 215 +/- 26% (mean +/- SE) of baseline at a cortical brain temperature of 30.9 +/- 0.5 degrees C and a rectal temperature of 37.5 +/- 0.1 degrees C. During rewarming, as brain temperature increased, cortical cerebral blood flow decreased. The cerebral vasodilatory response to hypothermia may explain its protective effects during and after cerebral ischemia.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Flow Velocity
  • Body Temperature*
  • Brain / physiology*
  • Cerebral Cortex / blood supply*
  • Cerebrovascular Circulation / physiology*
  • Hot Temperature
  • Hypothermia, Induced*
  • Male
  • Rats
  • Rats, Wistar