Callosal atrophy parallels decreased cortical oxygen metabolism and neuropsychological impairment in Alzheimer's disease

Arch Neurol. 1993 Oct;50(10):1070-4. doi: 10.1001/archneur.1993.00540100061017.


Objective: To evaluate the relationship of corpus callosum atrophy to cerebral cortical oxygen metabolism and cognitive function in patients with Alzheimer's disease.

Design: Prospective clinicoradiologic correlation with magnetic resonance imaging and positron emission tomography.

Setting: A university hospital.

Patients, participants: Ten right-handed male patients with Alzheimer's disease, aged 46 to 70 years (mean +/- SD 57 +/- 6 years), and 14 age- and sex-matched right-handed control subjects.

Main outcome measures: The midsagittal corpus callosum areas (on T1-weighted magnetic resonance images), cerebral metabolic rate of oxygen (measured with positron emission tomography using the oxygen-15 steady-state technique), and the IQs of the Wechsler Adult Intelligence Scale.

Results: Compared with control subjects, the patients had significantly decreased callosal areas with a posterior predominance of the degree of atrophy. The area of anterior and posterior halves of the corpus callosum had a significant correlation with the value of oxygen metabolism in the frontal and parietotemporo-occipital association cortices, respectively. The total area of the corpus callosum was significantly related to the total and verbal IQs of the Wechsler Adult Intelligence Scale.

Conclusion: Atrophy of corpus callosum reflects the severity and pattern of cortical damage associated with hypometabolism and cognitive impairment in Alzheimer's disease.

MeSH terms

  • Aged
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology*
  • Alzheimer Disease / psychology
  • Cerebral Cortex / diagnostic imaging
  • Cerebral Cortex / metabolism*
  • Cognition
  • Corpus Callosum / pathology*
  • Humans
  • Intelligence Tests
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Oxygen / metabolism*
  • Prospective Studies
  • Tomography, Emission-Computed
  • Wechsler Scales


  • Oxygen