Pretreatment of rats with pulsed electromagnetic fields enhances regeneration of the sciatic nerve

Bioelectromagnetics. 1993;14(4):353-9. doi: 10.1002/bem.2250140407.


Regeneration of the sciatic nerve was studied in rats pretreated in a pulsed electromagnetic field (PEMF). The rats were exposed between a pair of Helmholtz coils at a pulse repetition rate of 2 pps at a field density of 60 or 300 microT. The PEMF treatment was then discontinued. After an interval of recovery, regeneration of the sciatic nerve was initiated by a crush lesion. Regeneration of sensory fibers was measured by the "pinch test" after an additional 3-6 days. A variety of PEMF pretreatments including 4 h/day for 1-4 days or exposure for 15 min/day during 2 days resulted in an increased regeneration distance, measured 3 days after the crush lesion. This effect could be demonstrated even after a 14-day recovery period. In contrast, pretreatment for 4 h/day for 2 days at 60 microT did not affect the regeneration distance. The results showed that PEMF pretreatment conditioned the rat sciatic nerve in a manner similar to that which occurs after a crush lesion, which indicates that PEMF affects the neuronal cell body. However, the mechanism of this effect remains obscure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Electric Stimulation Therapy / methods*
  • Electromagnetic Fields*
  • Female
  • Nerve Regeneration / radiation effects*
  • Rats
  • Rats, Sprague-Dawley
  • Sciatic Nerve / injuries
  • Sciatic Nerve / physiology*
  • Sciatic Nerve / radiation effects*
  • Time Factors