Abstract
Fifteen 7-16-year-old patients, treated in 1981-1984 for acute lymphoblastic leukemia (ALL) in first complete remission, were studied. As a central nervous system prophylaxis, all the children were treated with repeated methotrexate (MTX) instillations, but none were irradiated. The study protocol included magnetic resonance (MR) and a battery of neuropsychological tests. Small, punctate white-matter lesions were found by MR in eight children, probably minor vascular lesions. All the children were within normal intelligence range with a mean total WISC-R IQ of 109. Minor neuropsychologic problems were found in two patients, while one child showed a more extensive specific learning disorder in school.
MeSH terms
-
Adolescent
-
Atrophy
-
Brain / pathology
-
Brain Diseases / chemically induced*
-
Brain Diseases / diagnostic imaging
-
Brain Diseases / pathology
-
Child
-
Child, Preschool
-
Follow-Up Studies
-
Humans
-
Infusions, Intravenous
-
Injections, Spinal / adverse effects
-
Learning Disabilities / chemically induced
-
Learning Disabilities / complications
-
Magnetic Resonance Imaging
-
Methotrexate / administration & dosage
-
Methotrexate / adverse effects*
-
Neuropsychological Tests
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
-
Survival Rate
-
Survivors / psychology
-
Tomography, X-Ray Computed