Anti-bovine viral diarrhoea virus antibodies in adult Zambian patients infected with the human immunodeficiency virus

Int J STD AIDS. Sep-Oct 1993;4(5):300-2. doi: 10.1177/095646249300400510.

Abstract

Bovine viral diarrhoea (BVD) virus is a cosmopolitan pestivirus of animals which is associated with diarrhoea, immunosuppression and synergy with other pathogens. This study was conducted to establish the prevalence of anti-BVD virus antibodies in healthy Zambian adults and those with asymptomatic and symptomatic HIV disease. Sera from 1159 adults were tested for anti-BVD virus antibodies using the indirect immunofluorescence test and the confirmatory Western blot. Of the 1159 sera examined, 180 (15.5%) showed significantly elevated titres of anti-BVD antibodies. These included 70 out of 477 (14.7%) HIV-negative healthy adults; 73 out of 480 (15.2%) of HIV-positive asymptomatic individuals; 23 out of 129 (17.8%) HIV-seropositive patients with associated illnesses excluding diarrhoea; and 14 out of 73 (19.2%) of HIV-seropositive patients with chronic diarrhoea. HIV-seropositive patients with chronic diarrhoea or associated illnesses appear to have significantly increased seroprevalence of anti-BVD virus antibodies (P = > 0.01). The mechanism of interaction between BVD virus and HIV infections and the synergistic effects with other opportunistic pathogens in humans requires definition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Animals
  • Antibodies, Viral / blood*
  • Bovine Virus Diarrhea-Mucosal Disease* / etiology
  • Bovine Virus Diarrhea-Mucosal Disease* / microbiology
  • Cattle
  • Chronic Disease
  • Diarrhea / etiology
  • Diarrhea / microbiology*
  • Diarrhea Viruses, Bovine Viral / immunology*
  • HIV Infections / complications
  • HIV Infections / microbiology*
  • HIV Seronegativity
  • Humans
  • Seroepidemiologic Studies

Substances

  • Antibodies, Viral