Central hyperexcitability triggered by noxious inputs

S B McMahon; G R Lewin; P D Wall

doi:10.1016/0959-4388(93)90062-4

Central hyperexcitability triggered by noxious inputs

Curr Opin Neurobiol. 1993 Aug;3(4):602-10. doi: 10.1016/0959-4388(93)90062-4.

Authors

S B McMahon¹, G R Lewin, P D Wall

Affiliation

¹ Department Physiology, St Thomas's Hospital Medical School, London, UK.

PMID: 8219728
DOI: 10.1016/0959-4388(93)90062-4

Abstract

Repetitive activity in unmyelinated sensory afferent neurones, arising from electrical stimuli, tissue injury or nerve damage, can induce long-lasting sensitization in dorsal horn neurones. This process can be blocked by antagonists of the NMDA receptor. In the past year it has emerged that sensory neuropeptides and nitric oxide are also essential mediators of this phenomenon.

Publication types

Review

MeSH terms

Afferent Pathways / physiology*
Animals
Electric Stimulation
Humans
Models, Neurological*
Nerve Growth Factors / physiology
Neurons, Afferent / physiology*
Neuropeptides / physiology
Nitric Oxide / physiology
Receptors, N-Methyl-D-Aspartate / physiology
Spinal Cord / physiology*
Synaptic Transmission
Wounds and Injuries / physiopathology

Substances

Nerve Growth Factors
Neuropeptides
Receptors, N-Methyl-D-Aspartate
Nitric Oxide