Tolerance to intravenous midazolam as a result of oral benzodiazepine therapy: a potential problem for the provision of conscious sedation in dentistry

Anesth Pain Control Dent. 1993 Spring;2(2):94-7.


Tolerance to the sedative effects of the benzodiazepine group of drugs is well documented. A brief review of the literature is presented. Three cases in which tolerance to intravenous midazolam became apparent and caused a significant problem during the attempted induction of conscious sedation are described. The patients were all concurrently receiving treatment with other benzodiazepines. It is recommended that patients with a history of regular, current benzodiazepine use be treated with caution with regard to this type of sedation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anesthesia, Dental / methods*
  • Benzodiazepines / adverse effects*
  • Benzodiazepines / pharmacokinetics
  • Benzodiazepines / therapeutic use
  • Conscious Sedation / methods*
  • Drug Tolerance
  • Female
  • Humans
  • Male
  • Midazolam / administration & dosage
  • Midazolam / therapeutic use*
  • Middle Aged


  • Benzodiazepines
  • Midazolam